Antidiabetic Activities of Medicinal Plants in Traditional Recipes and Candidate Antidiabetic Compounds from Hydnophytum formicarum Jack. Tubers

Pharmacognosy Research,2022,14,1,89-99.DOI:10.5530/pres.14.1.13Published:December 2021Type:Original ArticleAuthors:Mingkwan Rachpirom, Louis R Barrows, Suriyan Thengyai, Chitchamai Ovatlarnporn, Chonlatid Sontimuang, Pitchanan Thiantongin, and Panupong Puttarak Author(s) affiliations:Mingkwan Rachpirom1,2, Barrows3, Thengyai4, Ovatlarnporn5, Sontimuang6, Thiantongin7, Puttarak1,2,* 1Department of Pharmaceutical Botany, Faculty Sciences, Prince Songkla University, Hat-Yai, Songkhla, THAILAND. 2Phytomedicine Biotechnology Excellence Center, 3Department Pharmacology Toxicology, College Pharmacy, University Utah, Salt Lake City, UT, USA. 4Drug Cosmetics Walailak Thasala, Nakhonsithammarat, 5Department Chemistry, 6Department Thai Massage Midwifery, Traditional Medicine, 7Faculty Alternative Ubon-Ratchathani Rajabhat Meung, Ubon-Ratchathani, Abstract:Introduction: Wang-Nam-Yen hospital recipe used as a traditional antidiabetic for long time, but its beneficial properties have not been described. Materials Methods: Antidiabetic mechanisms including anti-α-glucosidase, anti-α-amylase, anti-dipeptidyl-peptidase-4, antioxidant, anti-inflammatory activities, wound healing effects 26 medicinal plants that make up the preparation were investigated. Results: Interestingly, most in this study inhibited α-glucosidase α-amylase at excellent levels with higher potency than standard acarbose (18.2% ± 0.5). Hydnophytum formicarum, Urceola minutiflora, Lagerstroemia speciosa, DPP-4 more 70% inhibition 50 μg/mL (82.8%± 0.8, 71.9% 0.3, 71.1% 0.1, respectively compared Diprotin A μg/mL, 90.1% 0.4). Terminalia arjuna showed highest all anti-oxidation assays. Andrographis paniculata NO production 2.4, which was effective indomethacin (34.3% 2.4). Most herbs contained high amounts terpenoids flavonoids, might play an important role activity. The results demonstrated H. formicarum extract exhibited anti-DPP-4 activity (IC50 = 33.87 0.02 μg/mL). When ethanolic isolated, Palmitic acid (1) inhibitory IC50 value 73.82 2.64 mixture stigmasterol (2) ß-sitosterol (3) 78.58 0.92 μg/mL. Conclusion: Many possessed predictive treatment. also suggest possibility further use isolated compounds diabetic drug future. Keywords:Anti-DPP-4 activity, Anti-inflammation Anti-α-amylase Anti-α-glucosidase recipe., Antioxidant activityView:PDF (1.16 MB) Full Text